References
Abiodun, O.O., Nwadike, N., Sosanya, A.S., Ogunleye, F.N. (2020).
Ocimum gratissimum Linn (Lamiaceae) protects Wistar rats
against inflammation and oxidative stress in Trinitrobenzene
sulphonic acid induced colitis. Thai Journal of Pharmaceutical
Sciences, 8, 44(3). doi: https://doi.org/10.56808/3027-7922.2445
Akkol,E.K., Yalçın, F.N.,Kaya, D.,Çalış, İ.,Yesilada, E.,Ersöz,T.(2008).In
vivo anti-inflammatory and antinociceptive actions of some
Lamium species. Journal of Ethnopharmacology,
19;118(1):166-172. doi: 10.1016/j.jep.2008.04.001.
Algieri, F., Rodriguez-Nogales, A., Vezza, T.,Garrido-Mesa, J.,GarridoMesa, N.,Utrilla, M.P., González-Tejero, M.R., Casares-Porcel,
M., Molero-Mesa, J., et al.( 2016). Anti-inflammatory activity of
hydroalcoholic extracts of Lavandula dentata L. and Lavandula
stoechas L. Journal of ethnopharmacology, 22;190:142-58. doi:
10.1016/j.jep.2016.05.063.
Ali, T., Javan, M., Sonboli, A., Semnanian, S. (2012). Evaluation of the
antinociceptive and anti-inflammatory effects of essential oil of
Nepeta pogonosperma Jamzad et Assadi in rats. DARU Journal
of Pharmaceutical Sciences, 4;20(1):48. doi: 10.1186/2008-
2231-20-48.
Al-Mijalli, S.H., Mrabti, H.N., Elbouzidi, A., Ashmawy, N.S., Batbat, A.,
Abdallah, E.M., Laaboudi, W., Aladhadh, M., Alshabrmi, F.M.,
Alnasser, S.M., Addi, M. (2025). Thymus serpyllum L.
Essential Oil: Phytochemistry and in Vitro and in Silico
Screening of Its Antimicrobial, Antioxidant and AntiInflammatory Properties. Phyton (0031-9457), 1,94(1).
Alves-Silva, J.M., Pedreiro, S., Cavaleiro, C., Cruz, M.T., Figueirinha, A.,
Salgueiro, L. (2023). Effect of Thymbra capitata (L.) Cav. on
inflammation, senescence and cell migration. Nutrients,
17,15(8),1930.
Ananthakrishnan, A.N., Higuchi, L.M., Huang, E.S., et al. (2012). Aspirin,
nonsteroidal anti-inflammatory drug use, and risk for Crohn
disease and ulcerative colitis: a cohort study. Ann Intern Med.,
156(5),350–9.
Ananthakrishnan, A.N. (2015). Epidemiology and risk factors for IBD. Nat
Rev Gastroenterol Hepatol, 12, 205–217.
Ananthakrishnan, A.N., Long, M.D., Martin, C.F., et al., (2013). Sleep
disturbance and risk of active disease in patients with Crohn’s
disease and ulcerative colitis. Clin Gastroenterol Hepatol,
11(8),965–71.
Andrade, J. M., Faustino, C., & Garcia, C. (2018). Rosmarinus officinalis
L.: an update review of its phytochemistry and biological
activity. Future Science OA, 4(4), FSO283.
https://doi.org/10.4155/fsoa-2017-0124
Annese, V. (2020). Genetics and epigenetics of IBD. Pharmacol. Res, 159,
104892. https://pubmed.ncbi.nlm.nih.gov/32464322.
Arega, M., Nardos, A., Debella, A., Dereje, B., Terefe, L., Abebe, A.
(2023). Evaluation of anti-inflammatory activity of the
methanol extracts of Premna schimperi Engl (Lamiaceae) leaves
in rats. Journal of Experimental Pharmacology, 14;15:437-447.
doi: 10.2147/JEP.S432615. 14; 15: 437-447.
Asgarpanah, J., Sarabian, S., & Ziarati, P. (2013). Essential oil
of Nepeta genus (Lamiaceae) from Iran: a review. Journal of
Essential Oil Research, 26(1), 1–12.
doi.org/10.1080/10412905.2013.851040.
Bager, P., Simonsen, J., Nielsen, N.M., et al. (2012). Cesarean section and
offspring’s risk of inflammatory bowel disease: a national cohort
study. Inflamm Bowel Dis,18(5),857–62.
Bahmani, M., Shirzad, H., Majlesi, M., Shahinfard, N., Rafieian-Kopaei, M.
(2014). A review study on analgesic applications of Iranian
medicinal plants. Asian Pacific Journal of Tropical Medicine, 7,
S43–S53.
Bai, M., Guo, H., Zheng, X.Y. (2023). Inflammatory bowel disease
and Clostridium difficile infection: clinical presentation,
diagnosis, and management. Therap Adv Gastroenterol.,
28,16,17562848231207280. doi: 10.1177/17562848231207280.
Baricevic, D., Sosa, S., Della Loggia, R., Tubaro, A., Simonovska, B.,
Krasna, A., Zupancic, A. (2001). Topical anti-inflammatory
activity of Salvia officinalis L. leaves: the relevance of ursolic
acid. J Ethnopharmacol. ,75(2-3),125-132. doi: 10.1016/s0378-
8741(00)00396-2.
Barreto, R.S., Quintans, J.S., Amarante, R.K., Nascimento, T.S., Amarante,
R.S., Barreto, A.S., Pereira, E.W.et al. (2016). Evidence for the
involvement of TNF-α and IL-1β in the antinociceptive and antiinflammatory activity of Stachys lavandulifolia Vahl.
(Lamiaceae) essential oil and (-)-α-bisabolol, its main
compound, in mice. Journal of Ethnopharmacology, 15;191:9-
18. doi: 10.1016/j.jep.2016.06.022.
Baumgart, D.C., Sandborn, W.J. (2007). Gastroenterology 2: Inflammatory
bowel disease: clinical aspects and established and evolving
therapies. Lancet, 18, 379–87. doi: 10.1016/S0140-
67360760751-X.
Bekut, M., Brkic, S., Kladar, N., Dragovi ´ c, G, Gavari ´ c, N., Bozin, B.
(2018). Potential of selected Lamiaceae plants in anti(retro)viral
therapy.Pharmacological Research, 133:301-314. doi:
10.1016/j.phrs.2017.12.016.
Bernstein, C.N., Singh, S., Graff, L.A., et al. (2010). A prospective
population-based study of triggers of symptomatic flares in IBD.
Am J Gastroenterol,105(9),1994–2002.
Borowitz, S.M. (2023). The epidemiology of inflammatory bowel disease:
Clues to pathogenesis? Front Pediatr., 17;10:1103713. doi:
10.3389/fped.2022.1103713.
Brindisi, M., Bouzidi, C., Frattaruolo, L., Loizzo, M.R., Cappello, M.S.,
Dugay, A., Deguin, B, et al. (2021). New insights into the
antioxidant and anti-inflammatory effects of Italian Salvia
officinalis leaf and flower extracts in lipopolysaccharide and
tumor-mediated inflammation models.
Antioxidants,19,10(2),311.
Kazemivash and Ziarati JFBE 8(1): 80-92,2025
89
Brune, K., Patrignani, P. (2015). New insights into the use of currently
available nonsteroidal anti-inflammatory drugs. J Pain Res.,
20,8,105-18. doi: 10.2147/JPR.S75160.
Byun, M.W. (2014). Schizonepeta tenuifolia ethanol extract exerts antiinflammatory activity through the inhibition of TLR4 signaling
in lipopolysaccharide-stimulated macrophage cells. J. Med.
Food, 17(3):350-6. doi: 10.1089/jmf.2013.2928.
Çadirci, E., Süleyman, H., Gürbüz, P., Uz, A.Y., Güvenalp, Z., Demirezer,
L.Ö. (2012). Anti-inflammatory effects of different extracts from
three Salvia species. Turkish Journal of Biology, 36(1),59-64.
Cadwell, K., Patel, K.K., Maloney, N.S., Liu, T.C., Ng, A.C., Storer, C.E.,
et al. (2010). Virus-plus-susceptibility gene interaction
determines Crohn’s disease gene Atg16L1 phenotypes in
intestine. Cell, 141,1135–45.
Cao, C., Jin, R., Wei, H., Liu, Z., Ni, S., Liu, G.J., Young, H.A.,Chen,
X.,Liu,G. (2020). Adaptive in vivo device for theranostics of
inflammation: Real-time monitoring of interferon-γ and aspirin.
Acta Biomater., 1,101,372-383. doi:
10.1016/j.actbio.2019.10.021.
Carovic-Stanko, K., Petek, M., Grdi sa, M. (2016). Medicinal plants of the
family Lamiaceae as functional foods—a review,” Czech
Journal of Food Sciences, 34 (5), 377–390.
Çelik, G., Kılıç, G., Kanbolat, S. (2021). Biological activity, and volatile
and phenolic compounds from five Lamiaceae species. Flavour
and Fragrance Journal, 36 (2), 223–232.
Chan, S.S., Luben, R., Bergmann, M.M., et al. (2011). Aspirin in the
aetiology of Crohn’s disease and ulcerative colitis: a European
prospective cohort study. Aliment Pharmacol Ther, 34(6),649–
55.
Chassaing, B., Koren, O., Goodrich, J.K., Poole, A.C., Srinivasan, S., et al.
(2015). Dietary emulsifiers impact the mouse gut microbiota
promoting colitis and metabolic syndrome. Nature, 519,92–96.
Chehel Cheraghi, S., Ebrahimi Daryani, N., Ghabaee, M. (2016). A Survey
on Migraine Prevalence in Patients with Inflammatory Bowel
Disease, A Single Centre Experience. Middle East J Dig Dis.
,8(4), 282-288. doi: 10.15171/mejdd.2016.37.
Chen, C.Y., Leu, Y.L., Fang, Y., Lin, C.F., Kuo, L.M., Sung, W.C., Tsai,
Y.F., Chung, P.J., Lee, M.C., Kuo, Y.T., Yang, H.W. (2015).
Anti-inflammatory effects of Perilla frutescens in activated
human neutrophils through two independent pathways: Src
family kinases and Calcium. Scientific reports, 14,5(1),18204.
Chrysargyris, A. (2024). It Runs in the Family: The Importance of the
Lamiaceae Family Species. Agronomy, 14(6), 1274. Cimino, C.,
Maurel, O.M., Musumeci, T., Bonaccorso, A., Drago, F., Souto,
E.M.B. et al. (2021). Essential Oils: Pharmaceutical
Applications and Encapsulation Strategies into Lipid-Based
Delivery Systems. Pharmaceutics, 3; 13(3):327. doi:
10.3390/pharmaceutics13030327.
Cornish, J.A., Tan, E., Simillis, C., et al. (2008). The risk of oral
contraceptives in the etiology of inflammatory bowel disease: a
meta-analysis. Am J Gastroenterol , 103(9), 2394–400.
Crane, A.M., Bradbury, L., van Heel, D.A., McGovern, D.P., Brophy, S.,
Rubin, L., Siminovitch, K.A., Wordsworth, B.P., Calin, A.,
Brown, M.A. (2002). Role of NOD2 variants in spondylarthritis.
Arthritis Rheum ,46,1629–1633. doi: 10.1002/art.10329.
Cristea, V. (2014). Plante Vasculare: Diversitate, Sistematică, Ecologie S, i
Important, ă; Presa Universitara Clujeana: Cluj-Napoca,
Romania, ISBN 978-973-595-648-6.
Croteau, R., Kutchan, T.M., Lewis, N.G. (2000) Natural Products
(Secondary metabolites). In: Buchanan BB, Gruissem w, Jones
RL, editors. Biochemistry & molecular biology of plants.USA:
Courier companies, Inc, 1250-1318.
Dal Pra, V., Bisol, L.B., Detoni, S., Denti, M., Grando, J., Pollo, C.,
Pasquali, T.R., Hoffmann, A.E., Mazutti, M.A., Macedo, S.M.
(2011). Anti-inflammatory activity of fractionated extracts of
Salvia officinalis. Journal of Applied Pharmaceutical Science,
30,67-71.
Dalvi, A., Bargir, U.A., Natraj, G., Shah, I., Madkaikar, M. (2024).
Diagnosis and Management of Infections in Patients with
Mendelian Susceptibility toMycobacterial Disease. Pathogens,
25,13(3),203. doi: 10.3390/pathogens13030203.
de Lange, K.M., Barrett, J.C. (2015). Understanding inflammatorybowel
disease via immunogenetics. J. Autoimmun, 64, 91–100.
Dhawan, N.G., Ambrina, S.K., Prateek, S. (2013). A general appraisal of
Leonotis nepetifolia (L.) R. Br: An essential medicinal plant.
Env. Pharmacol. Life Sci., 2(8),118-121.
Dhayalan, M., Anitha Jegadeeshwari, L., Nagendra Gandhi N. (2015).
Biological activity sources from traditionally usedtribe and
herbal plants material. Asian Journal of Pharmaceutical and
Clinical Research, 8(6), 11–23.
Do, M.H., Choi, J.,Kim, Y.,Park, H.Y., Ha, S.K., Hur, J. (2019).
Schizonepeta tenuifolia reduces methylglyoxal-induced
cytotoxicity and oxidative stress in mesangial cells. J. Funct.
Food., 62, 103531. doi: 10.17221/504/2015-CJFS.
Dong, A. X., Xin, H. B., Li, Z. J., Liu, H., Sun, Y. Q., Nie, S.; Zhao, Z. N.,
Cui, R. et al. (2018). High Quality Assembly of the Reference
Genome for Scarlet Sage, Salvia Splendens, an Economically
Important Ornamental Plant. Giga Science7, giy068. doi:
10.1093/gigascience/giy068.
Draginic, N, Andjic, M., Jeremic, J., Zivkovic, V., Kocovic, A., Tomovic,
M., Bozin, B., Kladar, N., et al. (2022). Anti-inflammatory and
antioxidant effects of Melissa officinalis extracts: A comparative
study. Iran J Pharm Res. ,5, 21(1), e126561. doi: 10.5812/ijpr126561.
Dudareva, N., Klempien, A., Muhlemann, J.K., Kaplan, I. (2013).
Biosynthesis, Function and Metabolic Engineering of Plant
Volatile Organic Compounds. New Phytol., 198(1):16-32. doi:
10.1111/nph.12145.
Eftekhar, N., Moghimi, A., Mohammadian Roshan, N., Saadat, S.,
Boskabady, M.H. (2019). Immunomodulatory and antiinflammatory effects of hydro-ethanolic extract of Ocimum
basilicum leaves and its effect on lung pathological changes in
an ovalbumin-induced rat model of asthma. BMC
complementary and alternative medicine, 4;19(1):349. doi:
10.1186/s1290601927654.
Ek, W.E., D’Amato,M., Halfvarson,J.(2014).The history of genetics in
inflammatory bowel disease.Annals Gastro, 27,294–303.
El-Ansari, M.A., Aboutabl, E.A., Farrag, A.R., Sharaf, M., Hawas, U.W.,
Soliman, G.M., El-Seed,G.S.(2009).Phytochemical
andpharmacological studies on Leonotis leonurus.
Pharmaceutical biology, 47(9):894-902.
DOI:10.1080/13880200902942428.
Elpel, T. J. (1998). Botany in a day: Thomas J. Elpel's herbal field guide to
plant families. 3rd ed. Hollowtop Outdoor Primitive School.
Edition 6.2, October 2021.
Erfanian, N., Fazlpour, F., Safarpour, H., Askari, S.F., Foadoddini, M.,
Nasseri, S. (2024). Exploring the anti-inflammatory effects of
Lavandula stoechas L. extract on ovalbumin-induced acute
asthma in BALB/c mice. Avicenna Journal of Phytomedicine.
15(2):933-942. doi: 10.22038/AJP.2024.25175.
Florez, M.A., Tran, B.T., Wathan, T.K., DeGregori, J., Pietras, E.M., King,
K.Y. (2022). Clonal hematopoiesis: Mutation-specific adaptation
to environmental change. Cell Stem Cell., 2,29(6),882-904. doi:
10.1016/j.stem.2022.05.006.
Franke, A., McGovern, D.P., Barrett, J.C., Wang, K., Radford Smith, G.L.,
Ahmad, T, et al. (2010). Genome-wide meta-analysis increases
to 71 the number of confirmed Crohn’s disease susceptibility
loci. Nat Genet, 42, 1118–25.
Frezza, C., Venditti,A., Serafini,M., Bianco, A. (2019). Chapter 4
Phytochemistry, Chemotaxonomy, Ethnopharmacology, and
Nutraceutics of Lamiaceae. In Studies in Natural Products
Chemistry, Elsevier, 62, 125–178.
Gatti, L.V., Basso, L.S., Miller, J.B. et al. (2021). Amazonia as a carbon
source linked to deforestation and climate change. Nature, 595,
388–393
Gatti, S., Gelzoni, G., Catassi, G.N., Catassi, C. (2021). The Clinical
Spectrum of Inflammatory Bowel Disease Associated with
Specific Genetic Syndromes: Two Novel Pediatric Cases and a
Systematic Review. Front Pediatr., 26,9,742830. doi:
10.3389/fped.2021.742830.
Kazemivash and Ziarati JFBE 8(1): 80-92,2025
90
Ghafari, A.T., Jahidin, A.H., Zakaria, Y. & Hasan, M.H. 2021.
phytochemical screening and high-performance thin-layer
chromatography of Vitex trifolia leaves hydroalcoholic extract:
Potential anti-inflammatory properties. Journal of
Pharmaceutical Science International, 33(28A): 111-121.
https://doi.org/10.9734/jpri/2021/v33i28A31515.
Ghorbani, A., Esmaeilizadeh, M. (2017). Pharmacological properties of
Salvia officinalis and its components. Journal of traditional and
complementary medicine, 13, 7(4),433-440. doi:
10.1016/j.jtcme.2016.12.014.
Glocker, E.O., Frede, N., Perro, M., Sebire, N., Elawad, M.,Shah, N., et al.
(2010). Infant colitis – it’s in the genes. Lancet ,376,1272.
Glocker, E.O., Kotlarz, D., Boztug, K., Gertz, E.M., Schäffer, A.A., Noyan,
F., et al. (2009). Inflammatory bowel disease and mutations
affecting the interleukin-10 receptor. N Engl J Med, 361,2033–
45.
Hampe, J., Franke, A., Rosenstiel, P., Till, A., Teuber, M., Huse, K., et al.
(2007). A genome-wide association scan of nonsynonymous
SNPs identifies a susceptibility variant for Crohn disease in
ATG16L1. Nat Genet, 39, 207–11.
Hanauer, S.B. (2008). Review article: Evolving concepts in treatment and
disease modification in ulcerative colitis. Aliment Pharmacol
Ther.,27,15-21.
Haas, R. A., Crișan, I., Vârban, D., & Vârban, R. (2024). Aerobiology of
the Family Lamiaceae: Novel Perspectives with Special
Reference to Volatiles Emission. Plants, 13(12), 1687. doi:
10.3390/plants13121687.
Hosseinzadeh, H., Ramezani, M., Salmani, G.A. (2000). Antinociceptive,
anti-inflammatory and acute toxicity effects of Zataria multiflora
Boiss extracts in mice and rats. Journal of ethnopharmacology,
73(3):379-85. doi: 10.1016/s0378-8741(00)00238-5.
Hu, K., He, H., Yuan, X., Du, X., Liu, R., Yang, P., Yang, Q., Zhang, Y.,
Qiao, J. (2022). Carboxymethyl Chitosan Oligosaccharide
Holds Promise for Treatment of Stenosis Crohn's Disease. ACS
Pharmacol Transl Sci., 20,5(8), 562-572. doi:
10.1021/acsptsci.2c00035.
Hubbard-Lucey, V.M., Shono, Y., Maurer, K., West, M.L., Singer, N.V.,
Ziegler, C.G., et al. (2014). Autophagy Gene Atg16l1 Prevents
Lethal T Cell Alloreactivity Mediated by Dendritic Cells.
Immunity, 41,579–91.
Jain, P.L.B., Patel, S.R., Desai, M.A. (2022). Patchouli Oil: An Overview
on Extraction Method, Composition and Biological Activities. J.
Essent. Oil Res., 34, 1–11.
Joossens, M., Huys, G., Cnockaert, M., DePreter, V.,Verbeke, K., et al.
(2011). Dysbiosis of the faecal microbiota in patients with
Crohn’s disease and their unaffected relatives. Gut, 60,631–37.
doi: 10.1136/gut.2010.223263.
Jordamović, N., Pehlivanović, B., Nikšić, H., Gušić, I., Korić, E., Dedić,
M., Tuna-Repovac, B., Bečić, F., Durić, K. (2023). Antiproliferative and anti-inflammatory activity of triterpene extracts
from plant species belonging to Lamiaceae family. Boletín
Latinoamericano y del Caribe de Plantas Medicinales y
Aromáticas, 1, 22 (6).
Kaistha, A., Levine, J. (2014). Inflammatory bowel disease: the classic
gastrointestinal autoimmune disease. Current problems in
pediatric and adolescent health care, 44(11),328-34.
Kaplan, G.G., Ng, S.C. (2017). Understanding and preventing the global
increase of Inflammatory Bowel
Disease.Gastroenterology,152(2):313-321.e2. doi:
10.1053/j.gastro.2016.10.020.
Kaplan, G.G., Windsor, J.W. (2021). The four epidemiologic stages in the
global evolution of inflammatory bowel disease. Nat Rev
Gastroenterol Hepatol., 18,56–66. doi: 10.1038/s41575-020-
00360-x.
Kavitha, T., Nelson, R., Thenmozhi, R., Priya, E. (2012). Antimicrobial
activity and phytochemical analysis of Anisomeles malabarica
(L.). R.Br. J. Microbiol.Biotech, 2(1),1-5.
Kelayeh, T.P., Abedinzade, M., Ghorbani, A. (2019). A review on
biological effects of Lamium album (white dead nettle) and its
components. Journal of Herbmed Pharmacology, 9,8(3),185-
193.
Kenny, E.E., Pe’er, I., Karban, A., et al. (2012). A genome-wide scan of
Ashkenazi Jewish Crohn’s disease suggests novel susceptibility
loci. PLoS Genet ,8: e1002559.
Kigathi, R.N., Weisser, W.W., Reichelt, M., Gershenzon, J., Unsicker, S.B.
(2019). Plant Volatile Emission Depends on the Species
Composition of the Neighboring Plant Community. BMC Plant
Biol. 6;19(1):58. doi: 10.1186/s12870-018-1541-9.
Nayak, B., & Kumar, A. (2017). Activity of leukotrienes in
inflammation. Eur J Pharm And Med Res, 4, 207-15.
Lamb, C.A., Kennedy, N.A., Raine, T., et al. (2019). British Society of
Gastroenterology consensus guidelines on the management of
inflammatory bowel disease in adults. Gut, 68, 68(Suppl 3): s1-
s106. doi: 10.1136/gutjnl-2019-318484.
Larussa, T., Imeneo, M., Luzza, F. (2017). Potential role of nutraceutical
compounds in inflammatory bowel disease. World J.
Gastroenterol., 23, 2483–2492.
Lassen, K.G., Kuballa. P., Conway, K.L., et al. (2014). Atg16L1 T300A
variant decreases selective autophagy resulting in altered
cytokine signaling and decreased antibacterial defense. Proc
Natl Acad Sci U S A,111,7741–7746. doi:
10.1073/pnas.1407001111.
Lee, J.K., Song, Y.K., Lim, H.H. (2007). Analgesic and anti-inflammatory
effect of Scutellaria baicalensis. The Journal of Korean
Medicine,28(4),124-35.
Lengbiye, E.M., Messi, L.M., Rasoazanany, E.O., Luyeye, F.L., Mbing,
J.N., Kapepula, P.M., Ngombe, N.K., et al. (2020). Microscopic
Studies, Mineral composition and Bioactivity of Vitex madiensis
Oliv.(Lamiaceae). Discovery Phytomedicine,7(4),177-85.
Liu, J.Z., Van Sommeren, S., Huang, H., Ng, S.C., Alberts, R., Takahashi,
A., Ripke, S., Lee, J.C., Jostins, L., Shah, T., et al. (2015).
Association analyses identify 38 susceptibility loci for
inflammatory bowel disease and highlight shared genetic risk
across populations. Nat. Genet., 47, 979–986.
Loreto, F., Pollastri, S., Fineschi, S., Velikova, V. (2014). Volatile
Isoprenoids and Their Importance for Protection against
Environmental Constraints in the Mediterranean Area. Environ.
Exp. Bot., 103, 99–106.
Machiels, K., Joossens, M., Sabino, J., De Preter, V., Arijs, I., et al. (2014).
A decrease of the butyrate-producing species Roseburia hominis
and Faecalibacterium prausnitzii defines dysbiosis in patients
with ulcerative colitis. Gut ,63,1275–83. doi: 10.1136/gutjnl2013-304833.
Mamootil, D. (2023). Pediatric Ulcerative Colitis in Siblings. Cureus, 22,
15(6),e40829. doi: 10.7759/cureus.40829.
Mansourabadi, A.M., Sadeghi, H.M., Razavi, N., Rezvani, E. (2015). Antiinflammatory and analgesic properties of salvigenin, Salvia
officinalis flavonoid extracted. Adv Herb Med., 1(3): 31-41.
Maphosa, V., Adedapo, A.A., Moyo, B., Masika, P.J. (2012). Antiinflammatory and analgesic activities of the aqueous extract of
Leonotis leonurus leaves in rats. African Journal of
Biotechnology,11(26),6878-83.
Marchiando, A.M., Ramanan, D., Ding, Y., Gomez, L.E.,Hubbard-Lucey,
V.M., Maurer, K., et al.( 2013). A deficiency in the autophagy
gene Atg16L1 enhances resistance to enteric bacterial infection.
Cell Host Microbe, 14,216–24.
Marcuzzi, A., Bianco, A.M., Girardelli, M., Tommasini, A., Martelossi, S.,
Monasta, L., et al. (2013). Genetic and functional profiling of
Crohn's disease: autophagy mechanism and susceptibility to
infectious diseases. BioMed research international,2013,297501.
Mc Govern, D.P., Jones, M.R., Taylor, K.D., et al. (2010).
Fucosyltransferase 2 (FUT2) non-secretor status is associated
with Crohn’s disease. Hum Mol Genet,19,3468–3476.
Mi, Y., Tan, Y., Yu, Y. et al. (2025). Relationship between smoking status
and ulcerative colitis: a meta-analysis based on a case control
study. Sci Rep, 15, 13329.
Milevskaya, V.V., Prasad, S., Temerdashev, Z.A. (2019). Extraction and
Chromatographic Determination of Phenolic Compounds from
Medicinal Herbs in the Lamiaceae and Hypericaceae Families: A
Review. Microchem. J., 145, 1036–1049.
Kazemivash and Ziarati JFBE 8(1): 80-92,2025
91
Miranda-Bautista, J., Padilla-Suarez, C., Bouza, E., Munoz, P., Menchen,
L., Marin-Jimenez, I. (2014). Listeria monocytogenes infection
in inflammatory bowel disease patients: case series and review
of the literature. European journal of gastroenterology &
hepatology,26(11),1247-1252.
Mohammadi, F., Rahimi, K., Ahmadi, A., Hooshmandi, Z., Amini, S.,
Mohammadi, A. (2024). Anti-inflammatory effects of Mentha
pulegium L. extract on human peripheral blood mononuclear
cells are mediated by TLR-4 and NF-κB suppression. Heliyon,
4;10(1): e24040. doi: 10.1016/j.heliyon.2024.e24040.
Mohanta, O., Das, P.K., Panda, S.S. et al. (2025). Anti-inflammatory
activity of Leonotis nepetifolia leaf essential oil in LPSstimulated RAW 264.7 cells and its molecular mechanism of
action. Sci Rep 15, 32978
Murthy, A., Li, Y., Peng, I., et al. (2014). A Crohn’s disease variant in
Atg16l1 enhances its degradation by caspase 3. Nature,
506,456–462. doi: 10.1038/nature13044.
https://pubmed.ncbi.nlm.nih.gov/24553140
Napoli, E., Ruberto, G., Carrubba, A., Sarno, M., Muscarà, C., Speciale, A.,
Cristani, M., Cimino, F., Saija, A. (2022). Phenolic profiles,
antioxidant and anti-inflammatory activities of hydrodistillation
wastewaters from five Lamiaceae species. Molecules,
1,27(21),7427.
Ng, S.C., Bernstein CN, Vatn MH, Kakatos PL, Loftus EV, Tysk C, et al.
(2013). Geographic variability and environmental risk factors in
inflammatory bowel disease. Gut., 62,630–49. doi:
10.1136/gutjnl-2012-303661.
Nicolas, M., Lasalo, M., Chow, S., Antheaume, C., Huet, K., Hnawia, E.,
Guillemin, G.J., Nour, M., Matsui, M. (2023). Antiinflammatory activities of Coleus forsteri (formerly Plectranthus
forsteri) extracts on human macrophages and chemical
characterization. Frontiers in Pharmacology, 9;13:1081310. doi:
10.3389/fphar.2022.1081310.
Nielsen, H., Engberg, J., Ejlertsen, T., Bücker, R., Nielsen, H. (2012).
Short-term and medium-term clinical outcomes of
Campylobacter concisus infection. Clinical Microbiology and
Infection, 18(11), E459-E65.
Nieto, G. ( 2017). Biological activities of three essential oils of the
Lamiaceae family,” Medicines, 23;4(3):63. doi:
10.3390/medicines4030063.
Nsonde Ntandou, G.F., Dianzitoukoulou Matsima, L.D., Ingabire, J.,
Makemba Nkounkou, G.S., Nkundineza, J.C., ABENA, A.A.
(2020). Anti-Inflammatory and Central Analgesic Effect of the
Aqueous Extract of the Leaves of Vitex Madiensis Oliv
(Lamiaceae-Viticoïdeae). Sch Int J Tradit Complement Med,
3(1), 12-17, doi: 10.36348/sijtcm.2020.v03i01.002.
Ocaña-Fuentes, A., Arranz-Gutiérrez, E., Señorans, F.J., Reglero, G.
(2010). Supercritical fluid extraction of oregano (Origanum
vulgare) essentials oils: anti-inflammatory properties based on
cytokine response on THP-1 macrophages. Food and Chemical
Toxicology, 48(6):1568-75. doi: 10.1016/j.fct.2010.03.026.
Okoye, F.B., Obonga, W.O., Onyegbule, F.A., Ndu, O.O., Ihekwereme, CP.
(2014). Chemical composition and anti-inflammatory activity of
essential oils from the leaves of Ocimum basilicum L. and
Ocimum gratissimum L.(Lamiaceae). Int J Pharm Sci Res., 1,
5(6), 2174-80. doi:10.13040/IJPSR.0975-8232.5(6).2174-80 .
Oliveira, C.S., Barbosa, F.L., Ehrenfried, C.A., Rodrigues, T.E., Salvador,
M.J., Zampronio, A.R., Stefanello, M.É. (2024). Chemical
Constituents and Anti-inflammatory, Antinociceptive, and
Antioxidant Activities of Salvia melissiflora Aerial Parts.
Revista Brasileira de Farmacognosia, 34(2), 350-357.
Orlova, E., Yeh, A., Shi, M., Firek, B., Ranganathan, S. et al. (2019).
Genetic association and differential expression of PITX2 with
acute appendicitis. Hum Genet., 138(1), 37-47. doi:
10.1007/s00439-018-1956-2.
Osakabe, N., Yasuda, A., Natsume, M., Yoshikawa,T. (2004). Rosmarinic
acid inhibits epidermal inflammatory responses:
anticarcinogenic effect of Perilla frutescens extract in the murine
two-stage skin model. Carcinogenesis, 25(4): 549-57. doi:
10.1093/carcin/bgh034.
Ouakouak, H., Benchikha, N., Hassani, A., Ashour, M. L. (2019). Chemical
composition and biological activity of Mentha citrata Ehrh.,
essential oils growing in southern Algeria. Journal of Food
Science and Technology, 56 (12), 5346–5353, 2019. doi:
10.1007/s13197-019-04005-z.
Peloquin, J.M., Goel, G., Villablanca, E.J., Xavier, R.J. (2016).
Mechanisms of pediatric inflammatory bowel disease. Annu Rev
Immunol, 34,31–64. doi: 10.1146/annurev-immunol-032414-
112151.
Petersen, A.M., Halkjær, S.I., Gluud, L.L. (2015). Intestinal colonization
with phylogenetic group B2 Escherichia coli related to
inflammatory bowel disease: a systematic review and metaanalysis. Scandinavian journal of gastroenterology
,50(10),1199-207.
Pignatti, S. Flora d’Italia, vol. 2, Edagricole, Bologna, Italy, 1982.
Politeo, O., Bektašević, M., Carev, I., Jurin, M., Roje, M. (2018).
Phytochemical composition, antioxidant potential and
cholinesterase inhibition potential of extracts from Mentha
pulegium L. Chemistry & biodiversity, 15(12), e1800374.
Qnais, E.Y., Abu-Dieyeh, M., Abdulla, F.A., Abdalla, S.S. (2010). The
antinociceptive and anti-inflammatory effects of Salvia
officinalis leaf aqueous and butanol extracts. Pharmaceutical
Biology, 48(10):1149-56. doi: 10.3109/13880200903530763.
Qureshi O, Dua A. (2025). COX Inhibitors. StatPearls. Treasure Island
(FL): StatPearls, Available from:
https://www.ncbi.nlm.nih.gov/books/NBK549795/
Ramos Da Silva, L.R., Ferreira, O.O., Cruz, J.N.; De Jesus Pereira Franco,
C., Oliveira Dos Anjos, T., Cascaes, M.M., Almeida Da Costa,
W., et al. (2021). Lamiaceae Essential Oils, Phytochemical
Profile, Antioxidant, and Biological Activities. Evid. Based
Complement. Alternat Med. 2021:6748052. doi:
10.1155/2021/6748052.
Rath, T., Roderfeld, M., Blocher, S., Rhode, A., Basler, T., Akineden, O., et
al. (2011). Presence of intestinal Mycobacterium avium
subspecies paratuberculosis (MAP) DNA is not associated with
altered MMP expression in ulcerative colitis. BMC
gastroenterology, 11, 34.
Reshetnyak, V.I., Burmistrov, A.I., Maev, I.V. (2021). Helicobacter pylori:
Commensal, symbiont or pathogen? World J Gastroenterol., 21,
27(7), 545-560. doi: 10.3748/wjg.v27.i7.545.
https://pubmed.ncbi.nlm.nih.gov/33642828/.
Ricci, E.L., Toyama, D.O., Lago, J.H., Romoff, P., Kirsten, T.B., ReisSilva, T.M., Bernardi, M.M. (2010). Anti-nociceptive and antiinflammatory actions of Nepeta cataria L. var. citriodora
(Becker) Balb. essential oil in mice. J Health Sci Inst., 28(3),
289-93.
Russo, R., Corasantini, M.T., Bagetta, G., Morrone, L.A. (2015).
Exploration of Cytotoxicity of Some Essential Oils for
Translation in Cancer Therapy. Evid. Based Complement.
Alternat. Med., 2015:397821. doi: 10.1155/2015/397821.
Schieffer, K.M., Williams, E.D., Yochum, G.S., Koltun, W.A. (2016).
Review article: the pathogenesis of pouchitis. Aliment
Pharmacol Ther,44(8),817-35. doi: 10.1111/apt.13780.
Şener, K., Ekici, M., Gönülalan, E.M., Bodur, E. (2024). Comparative
Study of the Anti-Inflammatory Pathway Enzyme Activities of
Selected Plant Extracts from Lamiaceae Family. Fabad Journal
of Pharmaceutical Sciences, 1,49(1),197-210.
Serrano-Vega, R., Pérez-González, C., Alonso-Castro, Á.J., ZapataMorales, J.R., Pérez-Gutiérrez, S. (2020). Anti-inflammatory
and antinociceptive activities of Salvia keerlii. Pharmacognosy
Magazine,16(67). doi:10.4103/pm.pm_223_19.
https://phcog.com/article/view/2020/16/67/27-33
Shaw, S.Y., Blanchard, J.F., Bernstein, C.N. (2010). Association between
the use of antibiotics in the first year of life and pediatric
inflammatory bowel disease. Am J Gastroenterol,105(12),2687–
92.
SILVA, G.L., Luft, C., Lunardelli, A., Amaral, R.H., MELO DA, Donadio.
M.V., Nunes, F.B., et al. (2015). Antioxidant, analgesic and
anti-inflammatory effects of lavender essential oil. Anais da
Academia Brasileira de Ciências, 4,87,1397-1408.
Kazemivash and Ziarati JFBE 8(1): 80-92,2025
92
Stange, E.F., Travis, S.P., Vermeire, S., Beglinger, C., Kupcinkas, L.,
Geboes, K., Barakauskiene, A., Villanacci, V., Von Herbay, A.,
Warren, B.F., Gasche, C., Tilg, H., et al. (2006). European
Crohn's and Colitis Organisation. European evidence based
consensus on the diagnosis and management of Crohn's disease:
definitions and diagnosis. Gut. ,55 Suppl 1(Suppl 1), i1-15. doi:
10.1136/gut.2005.081950a.
Stefanaki, A., van Andel, T. (2021). Chapter 3—Mediterranean Aromatic
Herbs and Their Culinary Use. In Aromatic Herbs in Food;
Galanakis, C.M., Ed.; Academic Press: Cambridge, MA, USA,
pp. 93–121. ISBN 978-0-12-822716-9.
Sykora, J., Pomahacova, R., Kreslova, M., Cvalinova, D., Stych, P.,
Schwarz, J. (2018). Current global trends in the incidence of
pediatric-onset inflammatory bowel disease. World J Gastro,
24:2741–63. doi: 10.3748/wjg.v24.i25.2741.
Tae, K.S., Kim, S.J. (2012). Inhibition of iNOS and DNA Oxidation by
Methanol Extract of Schizonepeta tenuifolia. Trop. J. Pharm.
Res.,11, 397–404.
Takeuchi, H., Takahashi-Muto, C., Nagase, M., Kassai, M., Tanaka-Yachi,
R., Kiyose, C. (2020). Anti-inflammatory effects of extracts of
sweet basil (Ocimum basilicum L.) on a co-culture of 3T3-L1
adipocytes and RAW264. 7macrophages. Journal of oleo
science, 2,69(5),487-493. doi: 10.5650/jos.ess19321.
Tanko, Y., Magaji,G.M., Yerima,M.,Magaji, R.A., Mohammed,A.(2008).
Anti-nociceptive and anti-inflammatory activities of aqueous
leaves extract of Ocimum Gratissimum (Labiate) in Rodents.
African Journal of Traditional, Complementary and Alternative
Medicines, 22;5(2):141-6. doi: 10.4314/ajtcam.v5i2.31265.
Thrane, U. (2001). Development in the Taxonomy of Fusarium Species
Based on Secondary Metabolites.” In Fusarium: Paul E. Nelson
memorial symposium, edited by B. A. Summerell. St.Paul,
Minnesota: APS Press, 29-49.
Triantafillidis, J.K., Stanciu,C. (2012). Inflammatory bowel disease:
etiopathogenesis, diagnosis, treatment. 4th Edition,
“Technogramma”, 2012 Athens, Greece.
Trouillas, P., Calliste, C.A., Allais, D.P., Simon, A., Marfak, A., Delage, C.,
Duroux, J.L. (2003). Antioxidant, anti-inflammatory and
antiproliferative properties of sixteen water plant extracts used in
the Limousin countryside as herbal teas. Food chemistry,
1,80(3),399-407.
Tsianos, E.V., Katsanos, K.H., Tsianos, V.E. (2011). Role of genetics in
the diagnosis and prognosis of Crohn's disease. World J
Gastroenterol. ,17(48),5246-59. doi: 10.3748/wjg.v17.i48.5246. /
Uhlig, H.H., Schwerd, T., Koletzko, S., Shah, N., Kammermeier, J.,
Elkadri, A., Ouahed, J., Wilson, D.C., Travis, S.P., Turner, D., et
al. (2014). The Diagnostic Approach to Monogenic Very Early
Onset Inflammatory Bowel Disease. Gastroenterology, 147,
990–1007.e3.
Uritu, C. M., Mihai, C. T., Stanciu, G. D. (2018). Medicinal plants of the
family Lamiaceae in pain therapy: A review. Pain Research and
Management, 8;2018:7801543. doi: 10.1155/2018/7801543.
Valimehr, S., Sanjarian, F., Sabouni, F., Hashemi, H., Sharafi, A. (2015).
Anti-inflammatory effects of essential oil, aerial parts and hairy
roots extracts of Nepeta pogonosperma on rat brain mixed cells.
Research Journal of Pharmacognosy, 1,2(4),5-10.
Vohra, S., Punja, S., Jou, H., Schlegelmilch, M., Wilson, B., Spavor, M.,
Grundy, P., Mackie, A.S., Conway, J., Hartfield, D. (2021).
Comparative Effectiveness of Pediatric Integrative Medicine: A
Pragmatic Cluster-Controlled Trial. Children (Basel),
20,8(4),311. doi: 10.3390/children8040311.
wildflowers-and-weeds.com/Plant_Families/Lamiaceae.htm
Wang, B.S., Huang, G.J., Tai, H.M., Huang, M.H. (2012). Antioxidant and
anti-inflammatory activities of aqueous extracts of Schizonepeta
tenuifolia Briq. Food Chem. Toxicol., 50(3-4):526-31. doi:
10.1016/j.fct.2011.12.010.
Wang, X.D., Shi, S.L., Ma, Y.Z. (2022). Determination of essential oil from
Scutellaria baicalensis Georgi (Lamiaceae) by GC-MS, and
assessment of its insecticidal properties. Tropical Journal of
Pharmaceutical Research, 10,21(6),1249-54.
Xiao, L., Rao, J.N., Wang, J.Y. (2021). RNA-binding proteins and long
noncoding RNAs in intestinal epithelial autophagy and barrier
function. Tissue Barriers, 3, 9(2), 1895648. doi:
10.1080/21688370.2021.1895648.
Xu, P., Xi, Y., Kim, J.W., Zhang, M., Gao, C., Wang, Y., Xu, M., Wang,
X., Ren, S., Yang, D., Wang, Q., Xie, W. (2025). A loss-offunction human ADAR variant activates innate immune
response and promotes bowel inflammation. Nat Commun.,
29,16(1), 8560. doi: 10.1038/s41467-025-63554-4.
Yousuf, P.M., Noba, N.Y., Shohel, M., Bhattacherjee, R., Das, B.K. (2013).
Analgesic, anti-inflammatory and antipyretic effect of Mentha
spicata (Spearmint). British Journal of Pharmaceutical
Research, 3(4), 854-64.
Zhang, M., Chen, M., Hou, Y., Fan, C., Wei, H., Shi, L., Ma, G., Zhang, J.
(2021). Inflammatory and Cytotoxic Activities of Abietane
Terpenoids from Nepeta bracteata Benth. Molecules, 15, 26(18),
5603.
Zhao, X., Zhou, M. (2022). Chemical constituents of Schizonepeta
tenuifolia Briq. and their pharmacological effects. Molecules, 17,
27(16), 5249.
Zhu, Y., Li, X., Chen, J., Chen, T., Shi, Z., Lei, M., Fei, X. (2016). The
pentacyclic triterpene lupeol switches M1 macrophages to M2
and ameliorates experimental inflammatory bowel disease. Int
Immunopharmacol, 30, 74 - 84.
Zuzarte, M., Gonçalves, M.J., Cavaleiro, C., Cruz, M.T., Benzarti, A.,
Marongiu, B., Maxia, A., Piras, A., Salgueiro, L. (2013).
Antifungal and anti-inflammatory potential of Lavandula
stoechas and Thymus herba-barona essential oils. Industrial
Crops and Products, 1, 44, 97-103.