Recent advances in the extraction methods of essential oils and oleoresins from plant materials and its potential applications: A comprehensive review

Document Type : Review article

Authors

1 Department of Food Science & Technology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka

2 Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka

3 Instrument Center, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka

Abstract

Due to the important role of bioactive secondary metabolites in cosmeceuticals, functional foods, nutraceuticals, therapeutics, and health care, more attention has been paid to the extraction of active components using efficient extraction methods. Efficient, economical, and promising extraction routes are essential for resource recovery without compromising the quality and efficacy of the extracted products for desired applications. The present review emphasizes the recent developments and improvements in extraction methods of essential oils and oleoresins that have been achieved through different and innovative processing techniques and their diverse applicability. Besides, the trends of extraction techniques, the effect on essential oil glands in different extractions, industrial relevance, and optimization design were found important to industry professionals in realizing wider possibilities for selecting suitable extraction methods and developing new sustainable bioactive compounds-based formulations. In addition, this review facilitates the academics to select the effective extraction method in their research as extraction is the first and crucial part of plant-based research. The study revealed that the extraction methods developed using the combinations of novel technologies such as microwave assisted, ultrasound assisted, enzyme assisted, and supercritical fluid extraction were effective and efficient for the extraction of both essential oils and oleoresins. The extracts' applications are widening due to the advance in the delivery systems, such as micro and nanoencapsulation technologies.

Keywords

Main Subjects

Abbas, A., Anwar, F., & Ahmad, N. (2017). Variation in Physico-chemical Composition and Biological Attributes of Common Basil Essential Oils Produced by Hydro-distillation and Super Critical Fluid Extraction. Journal of Essential Oil-Bearing Plants, 20(1), 95–109.
Abd El-Gaber, A. S., El Gendy, A. N. G., Elkhateeb, A., Saleh, I. A., & El-Seedi, H. R. (2018). Microwave Extraction of Essential Oil from Anastatica hierochuntica (L): Comparison with Conventional Hydro-Distillation and Steam Distillation. Journal of Essential Oil-Bearing Plants, 21(4), 1003–1010.
Abdellatif, F., & Hassani, A. (2015). Chemical composition of the essential oils from leaves of Melissa officinalis extracted by hydrodistillation, steam distillation, organic solvent and microwave hydrodistillation. Journal of Materials and Environmental Science, 6(1), 207–213.
Almeida, R. N., Soares, R. de P., & Cassel, E. (2018). Fractionation process of essential oils by batch distillation. Brazilian Journal of Chemical Engineering, 35(3), 1129–1140.
Amaresh, A., P, G., khan, S., & R Zari, S. (2017). Comparative study of microwave assisted hydro-distillation with conventional hydro-distillation for extraction of essential oil from Piper betle L. Biosciences, Biotechnology Research Asia, 14(1), 401–407.
Amiri, N., Afsharmanesh, M., Salarmoini, M., Meimandipour, A., Hosseini, S. A., & Ebrahimnejad, H. (2021). Nanoencapsulation (in vitro and in vivo) is an efficient technology to boost the potential of garlic essential oil as an alternative for antibiotics in broiler nutrition. Animal, 15(1), 100022.
Ananingsih, V. K., Soedarini, B., & Karina, E. (2020). Separation of Oleoresin from Nutmeg Using Ultrasound Assisted Extraction and Hexane as Solvent. IOP Conference Series: Materials Science and Engineering, 854(1).
Ansarifar, E., & Moradinezhad, F. (2022). Encapsulation of thyme essential oil using electrospun zein fiber for strawberry preservation. Chemical and Biological Technologies in Agriculture, 9(1), 1–11.
Asbahani, A. El, Miladi, K., Badri, W., Sala, M., Addi, E. H. A., Casabianca, H., Mousadik, A. El, Hartmann, D., Jilale, A., Renaud, F. N. R., Elaissari, A., & Lyon, C. B. (2015). Essential oils : From extraction to encapsulation. International Journal of Pharmaceutics, 483(1–2), 220–243.
Ashraf, M. A., Iqbal, M., Rasheed, R., Hussain, I., Riaz, M., & Arif, M. S. (2018). Environmental stress and secondary metabolites in plants: an overview. Plant metabolites and regulation under environmental stress, 153-167.
Ayaz, M., Sadiq, A., Junaid, M., Ullah, F., Subhan, F., & Ahmed, J. (2017). Neuroprotective and anti-ageing potentials of essential oils from aromatic and medicinal plants. Frontiers in Aging Neuroscience, 9(MAY), 1–16.
Ayub, M. A., Hanif, M. A., Sarfraz, R. A., & Shahid, M. (2018). Biological activity of boswellia serrata roxb. Oleo gum resin essential oil: Effects of extraction by supercritical carbon dioxide and traditional methods. International Journal of Food Properties, 21(1), 808–820.
Azmin, S. N. H. M., Manan, Z. A., Alwi, S. R. W., Chua, L. S., Mustaffa, A. A., & Yunus, N. A. (2016). Herbal processing and extraction technologies. Separation and Purification Reviews, 45(4), 305–320.
Baby, K. C., & Ranganathan, T. V. (2016a). Effect of enzyme pre-treatment on extraction yield and quality of cardamom (Elettaria cardamomum maton.) volatile oil. Industrial Crops and Products, 89, 200–206.
Baby, K. C., & Ranganathan, T. V. (2016b). Effect of enzyme pre-treatment on extraction yield and quality of fennel (Foeniculum vulgare) volatile oil. Biocatalysis and Agricultural Biotechnology, 8, 248–256.
Baby, K. C., & Ranganathan, T. V. (2016c). Effect of enzyme pre-treatment on yield and quality of fresh green chilli (Capsicum annuum L.) oleoresin and its major capsaicinoids. Biocatalysis and Agricultural Biotechnology, 7, 95–101.
Belwal, T., Ezzat, S. M., Rastrelli, L., Bhatt, I. D., Daglia, M., Baldi, A., Prasad, H., Erdogan, I., & Kumar, J. (2018). A critical analysis of extraction techniques used for botanicals : Trends, priorities, industrial uses and optimization strategies. Trends in Analytical Chemistry, 100, 82–102.
Bhavaniramya, S., Vishnupriya, S., Al-Aboody, M. S., Vijayakumar, R., & Baskaran, D. (2019). Role of essential oils in food safety: Antimicrobial and antioxidant applications. Grain & Oil Science and Technology, 2(2), 49–55.
Bhushan, K., Chouhan, S., Tandey, R., Kumar, K., & Mehta, R. (2019). Critical analysis of microwave hydro diffusion and gravity as a green tool for extraction of essential oils : Time to replace traditional distillation. Trends in Food Science & Technology, 92(August), 12–21.
Borgarello, A. V., Mezza, G. N., Pramparo, M. C., & Gayol, M. F. (2015). Thymol enrichment from oregano essential oil by molecular distillation. Separation and Purification Technology, 153, 60–66.
Boulila, A., Hassen, I., Haouari, L., Mejri, F., Amor, I. Ben, Casabianca, H., & Hosni, K. (2015). Enzyme-assisted extraction of bioactive compounds from bay leaves (Laurus nobilis L.). Industrial Crops and Products, 74(2015), 485–493.
Burgos, N., Mellinas, A. C., García-Serna, E., & Jiménez, A. (2017). Nanoencapsulation of flavor and aromas in food packaging. In Food packaging (pp. 567-601). Academic Press.
Bustamante, J., van Stempvoort, S., García-Gallarreta, M., Houghton, J. A., Briers, H. K., Budarin, V. L., Matharu, A. S., & Clark, J. H. (2016). Microwave assisted hydrodistillation of essential oils from wet citrus peel waste. Journal of Cleaner Production, 137, 598–605.
Calo, J. R., Crandall, P. G., O’Bryan, C. A., & Ricke, S. C. (2015). Essential oils as antimicrobials in food systems - A review. Food Control, 54, 111–119.
Chen, G., Sun, F., Wang, S., Wang, W., Dong, J., & Gao, F. (2021). Enhanced extraction of essential oil from Cinnamomum cassia bark by ultrasound assisted hydrodistillation. Chinese Journal of Chemical Engineering, 36, 38–46.
Chen, M. H., & Huang, T. C. (2016). Volatile and nonvolatile constituents and antioxidant capacity of oleoresins in three Taiwan citrus varieties as determined by supercritical fluid extraction. Molecules, 21(12).
Cheng, X., Bi, L., Zhao, Z., & Chen, Y. (2015). Advances in Enzyme Assisted Extraction of Natural Products. Ic3me, 371–375.
Chouhan, S., Sharma, K., & Guleria, S. (2017). Antimicrobial Activity of Some Essential Oils—Present Status and Future Perspectives. Medicines, 4(3), 58.
Conde-Hernández, L. A., Espinosa-Victoria, J. R., Trejo, A., & Guerrero-Beltrán, J. (2017). CO2-supercritical extraction, hydro distillation and steam distillation of essential oil of rosemary (Rosmarinus officinalis). Journal of Food Engineering, 200, 81–86.
Dani, S. M., Anwar, F., Nurul, A. P., & Normalina, A. (2011). Solvent extraction of ginger oleoresin using ultrasound. Makara, Sains, 15(2), 163–167.
Dassoff, E. S., & Li, Y. O. (2019). Mechanisms and effects of ultrasound-assisted supercritical CO 2 extraction. Trends in Food Science and Technology, 86(March), 492–501.
de Alcantara Lemos, J., Oliveira, A. E. M., Araujo, R. S., Townsend, D. M., Ferreira, L. A. M., & de Barros, A. L. B. (2021). Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon. Biomedicine & Pharmacotherapy, 143, 112137.
Desai, M. A., & Parikh, J. (2015). Extraction of essential oil from leaves of lemongrass using microwave radiation: Optimization, comparative, kinetic, and biological studies. ACS Sustainable Chemistry and Engineering, 3(3), 421–431.
Desai, M., Parikh, J., & Parikh, P. A. (2010). Extraction of natural products using microwaves as a heat source. Separation and Purification Reviews, 39(1–2), 1–32.
Dilworth, L. L., Riley, C. K., & Stennett, D. K. (2017). Plant constituents: Carbohydrates, oils, resins, balsams, and plant hormones. In Pharmacognosy (pp. 61-80). Academic Press.
Dutta, S., & Bhattacharjee, P. (2015). Enzyme-assisted supercritical carbon dioxide extraction of black pepper oleoresin for enhanced yield of piperine-rich extract. Journal of Bioscience and Bioengineering, 120(1), 17–23.
Eblaghi, M., Khajehie, N., Golmakani, M. T., & Eskandari, M. H. (2016). Investigating the effects of microwave-assisted hydrodistillation on antioxidant and antifungal activities of Tanacetum polycephalum and Artemisia chamaemelifolia essential oils. Journal of Essential Oil Research, 28(6), 528–539.
Ekezie, F. G. C., Sun, D. W., & Cheng, J. H. (2017). Acceleration of microwave-assisted extraction processes of food components by integrating technologies and applying emerging solvents: A review of latest developments. Trends in Food Science & Technology, 67, 160-172.
Elyemni, M., Louaste, B., Nechad, I., Elkamli, T., Bouia, A., Taleb, M., Chaouch, M., & Eloutassi, N. (2019). Extraction of essential oils of Rosmarinus officinalis l. by two different methods: hydrodistillation and microwave assisted hydrodistillation. Scientific World Journal, 2019.
Essien, S. O., Young, B., & Baroutian, S. (2020). Recent advances in subcritical water and supercritical carbon dioxide extraction of bioactive compounds from plant materials. Trends in Food Science & Technology, 97, 156-169.
Fakhari, F., Maktabi, S., Fazlara, A., Bavarsad, N., & Pourmehdibrojeni, M. (2022). Comparison of antimicrobial and antioxidant activities of essential oil and Nano-emulsion of Ferulago angulata (Chavir) collected from the western regions of Iran. Iranian Veterinary Journal, 17(4), 71-86.
Filly, A., Fabiano-Tixier, A. S., Louis, C., Fernandez, X., & Chemat, F. (2016). Water as a green solvent combined with different techniques for extraction of essential oil from lavender flowers. Comptes Rendus Chimie, 19(6), 707–717.
Gandhi, K., Arora, S., & Kumar, A. (2017). Industrial applications of supercritical fluid extraction : A review Industrial applications of supercritical fluid extraction : A review. International Journal of Chemical Studies, 5(3), 336–340.
Gavahian, M., & Farahnaky, A. (2018). Ohmic-assisted hydrodistillation technology: A review. Trends in Food Science & Technology, 72, 153-161.
Gavahian, M., Farahnaky, A., Javidnia, K., & Majzoobi, M. (2012). Comparison of ohmic-assisted hydrodistillation with traditional hydrodistillation for the extraction of essential oils from Thymus vulgaris L . Innovative Food Science and Emerging Technologies, 14, 85–91.
Gavahian, M., Farahnaky, A., Majzoobi, M., Javidnia, K., Saharkhiz, M. J., & Mesbahi, G. (2011). Ohmic-assisted hydrodistillation of essential oils from Zataria multiflora Boiss (Shirazi thyme). International Journal of Food Science and Technology 2011, 2619–2627.
Gavahian, M., Farhoosh, R., Farahnaky, A., Javidna, K., & Shahidi, F. (2015). Ohmic-assisted hydrodistillation of essential oils from Mentha piperita. Iranian Food Science and Technology Research Journal, 11(3), 236–246.
Gavahian, M., Sastry, S., Farhoosh, R., & Farahnaky, A. (2020). Ohmic heating as a promising technique for extraction of herbal essential oils: Understanding mechanisms, recent findings, and associated challenges. Advances in food and nutrition research, 91, 227-273.
Ghazanfari, N., Mortazavi, S. A., Yazdi, F. T., & Mohammadi, M. (2020). Microwave-assisted hydrodistillation extraction of essential oil from coriander seeds and evaluation of their composition, antioxidant and antimicrobial activity. Heliyon, 6(9), e04893.
Golmakani, M., & Rezaei, K. (2008). Comparison of microwave-assisted hydrodistillation with the traditional hydrodistillation method in the extraction of essential oils from Thymus vulgaris L . Food Chemistry, 109, 925–930.
Golmakani, M. T., & Moayyedi, M. (2015). Comparison of heat and mass transfer of different microwave-assisted extraction methods of essential oil from Citrus limon (Lisbon variety) peel. Food Science and Nutrition, 3(6), 506–518.
González-Rivera, J., Duce, C., Falconieri, D., Ferrari, C., Ghezzi, L., Piras, A., & Tine, M. R. (2016). Coaxial microwave assisted hydrodistillation of essential oils from five different herbs (lavender, rosemary, sage, fennel seeds and clove buds): Chemical composition and thermal analysis. Innovative Food Science and Emerging Technologies, 33, 308–318.
Goodger, J. Q. D., Seneratne, S. L., Nicolle, D., & Woodrow, I. E. (2016). Foliar essential oil glands of Eucalyptus subgenus Eucalyptus (Myrtaceae) are a rich source of flavonoids and related nonvolatile constituents. PLoS ONE, 11(3), 1–18.
Granata, G., Riccobene, C., Napoli, E., & Geraci, C. (2022). Polymeric nanocapsules containing fennel essential oil: Their preparation, physicochemical characterization, stability over time and in simulated gastrointestinal conditions. Pharmaceutics, 14(4), 873.
Guenther, E., & Althausen, D. (1948). The essential oils (Vol. 1, p. 81). New York: Van Nostrand.
Hashmi, I., & Kim, J. G. (2015). Comparison of degradation studies in a biosimulator by continuous cultivation of Pseudomonas and indigenous microorganisms with varied dissolved oxygen concentrations. International Journal of Environment and Pollution, 19(2), 123–138.
Hazzoumi, Z., Moustakime, Y., & Amrani Joutei, K. (2020). Essential Oil and Glandular Hairs: Diversity and Roles. Essential Oils - Oils of Nature, 1–16.
Hemmatkhah, F., Zeynali, F., & Almasi, H. (2020). Encapsulated cumin seed essential oil-loaded active papers: Characterization and evaluation of the effect on quality attributes of beef hamburger. Food and Bioprocess Technology, 13(3), 533–547.
Hien Tran, T., Chinh Nguyen, D., Nguyen Phu, T. N., Van Thi, T. H., Nguyen Vo, D. V., Giang Bach, L., & Duy Nguyen, T. (2019). Research on lemongrass oil extraction technology (Hydrodistillation, microwave-assisted hydrodistillation). Indonesian Journal of Chemistry, 19(4), 1000–1007.
Jadhav, H., Jadhav, A., Morabiya, Y., Takkalkar, P., Qureshi, S. S., Baloch, A. G., ... & Mubarak, N. M. (2021). Combined impact of ultrasound pre-treatment and hydrodistillation on bioactive compounds and GC–MS analysis of Cinnamomum cassia bark extract. Waste and Biomass Valorization, 12(2), 807-821.
Jayanudin, Fahrurrozi, M., Wirawan, S. K., & Rochmadi. (2019). Preparation of chitosan microcapsules containing red ginger oleoresin using emulsion crosslinking method. Journal of Applied Biomaterials & Functional Materials, 17(1), 2280800018809917.
Jeyaratnam, N., Hamid, A., Kanthasamy, R., Hamid, A., Yuvaraj, A. R., & Olabode, J. (2016). Essential oil from Cinnamomum cassia bark through hydro distillation and advanced microwave assisted hydrodistillation. Industrial Crops & Products, 92, 57–66.
Kala, H. K., Mehta, R., Sen, K. K., Tandey, R., & Mandal, V. (2017). Strategizing method optimization of microwave-assisted extraction of plant phenolics by developing standard working principles for universal robust optimization. Analytical methods, 9(13), 2089-2103.
Kapustová, M., Granata, G., Napoli, E., Puškárová, A., Bučková, M., Pangallo, D., & Geraci, C. (2021). Nano encapsulated essential oils with enhanced antifungal activity for potential application on agri-food, material and environmental fields. Antibiotics, 10(1), 1–12.
Khorshidian, N., Yousefi, M., Khanniri, E., & Mortazavian, A. M. (2018). Potential application of essential oils as antimicrobial preservatives in cheese. Innovative Food Science and Emerging Technologies, 45, 62–72.
Kusuma, H. S., & Mahfud, M. (2016). Preliminary study: Kinetics of oil extraction from sandalwood by microwave-assisted hydrodistillation. IOP Conference Series: Materials Science and Engineering, 128(1).
Kusuma, H. S., & Mahfud, M. (2017). Comparison of kinetic models of oil extraction from sandalwood by microwave-assisted hydrodistillation. International Food Research Journal, 24(4), 1697–1702.
Kusuma, H. S., Putra, A. F. P., & Mahfud, M. (2016). Comparison of two isolation methods for essential oils from orange peel (Citrus auranticum L.) as a growth promoter for fish: Microwave steam distillation and conventional steam distillation. Journal of Aquaculture Research & Development, 7, 409.
Liu, Y., Yang, L., Zu, Y., Zhao, C., Zhang, L., Zhang, Y., Zhang, Z., & Wang, W. (2012). Development of an ionic liquid-based microwave-assisted method for simultaneous extraction and distillation for determination of proanthocyanidins and essential oil in Cortex cinnamomi. Food Chemistry, 135(4), 2514–2521.
Lo Presti, M., Ragusa, S., Trozzi, A., Dugo, P., Visinoni, F., Fazio, A., ... & Mondello, L. (2005). A comparison between different techniques for the isolation of rosemary essential oil. Journal of separation science, 28(3), 273-280. 
Lucchesi, M. E., Chemat, F., & Smadja, J. (2004). Solvent-free microwave extraction of essential oil from aromatic herbs : comparison with conventional hydrodistillation. Journal of Chromatography A, 1043, 323–327.
Madhumitha, B., ROY, A., KUMAR, S., & THANGAVELU, L. (2021). Green synthesis of copper nanoparticles using nutmeg oleoresin and its antimicrobial activity against oral pathogens. Journal of Complementary Medicine Research, 12(3), 21.
Mantell, C., Casas, L., Rodr´ıguez, M., & Enrique Mart´ınez de la Ossa. (2013). Supercritical Fluid Extraction. In S. Ramaswamy, H. Huang, & B. V. Ramarao (Eds.), Encyclopedia of Food and Health.
Mejri, J., Aydi, A., Abderpabba, M., & Mejri, M. (2018). Emerging extraction processes of essential oils: A review. Asian Journal of Green Chemistry, 2(3), 246–267.
Mendoza, N., & Silva, E. M. E. (2018). Introduction to phytochemicals: secondary metabolites from plants with active principles for pharmacological importance. Phytochemicals: Source of antioxidants and role in disease prevention, 25.
Miljanović, A., Bielen, A., Grbin, D., Marijanović, Z., Andlar, M., Rezić, T., ... & Dent, M. (2020). Effect of enzymatic, ultrasound, and reflux extraction pretreatments on the yield and chemical composition of essential oils. Molecules, 25(20), 4818.
Moghaddam, M., & Mehdizadeh, L. (2017). Chemistry of essential oils and factors influencing their constituents. In Soft chemistry and food fermentation (pp. 379-419). Academic Press.
Naboulsi, I., & Aboulmouhajir, A. (2018). Plants extracts and secondary metabolites, their extraction methods and use in agriculture for controlling crop stresses and improving productivity: A review. Acad. J. Med. Plants, 6(8), 223–240.
Nadeem, Azeem, M. W., & Jilani, M. I. (2017). Isolation of bioactive compounds from essential oils-A comprehensive review. Ijcbs, 12, 75–85.
Nurhadi, B., Saputra, R. A., Setiawati, T. A., Husein, S. N., Faressi, F. R., Utari, C. D., ... & Setiasih, I. S. (2020, February). Comparison of Curcuma domestica and Curcuma xanthorrhiza oleoresins extracted using maceration, Soxhlet, and ultrasound-assisted extraction (UAE). In IOP Conference Series: Earth and Environmental Science (Vol. 443, No. 1, p. 012074). IOP Publishing.
Pandey, A. K., Kumar, P., Singh, P., Tripathi, N. N., & Bajpai, V. K. (2017). Essential oils: Sources of antimicrobials and food preservatives. Frontiers in Microbiology, 7(JAN), 1–14.
Pateiro, M., Barba, F. J., Domínguez, R., Sant’Ana, A. S., Mousavi Khaneghah, A., Gavahian, M., Gómez, B., & Lorenzo, J. M. (2018). Essential oils as natural additives to prevent oxidation reactions in meat and meat products: A review. Food Research International, 113, 156–166.
Pateiro, M., Munekata, P. E. S., Sant’Ana, A. S., Domínguez, R., Rodríguez-Lázaro, D., & Lorenzo, J. M. (2021). Application of essential oils as antimicrobial agents against spoilage and pathogenic microorganisms in meat products. International Journal of Food Microbiology, 337, 108966. 6
Pavlić, B., Teslić, N., Zengin, G., Đurović, S., Rakić, D., Cvetanović, A., ... & Zeković, Z. (2021). Antioxidant and enzyme-inhibitory activity of peppermint extracts and essential oils obtained by conventional and emerging extraction techniques. Food Chemistry, 338, 127724.
Périno-Issartier, S., Ginies, C., Cravotto, G., & Chemat, F. (2013). A comparison of essential oils obtained from lavandin via different extraction processes: Ultrasound, microwave, turbohydrodistillation, steam and hydrodistillation. Journal of Chromatography A, 1305, 41-47.
Picot-Allain, C., Mahomoodally, M. F., Ak, G., & Zengin, G. (2021). Conventional versus green extraction techniques: A comparative perspective. Current Opinion in Food Science, 40, 144–156.
Pires, V. P., Almeida, R. N., Wagner, V. M., Lucas, A. M., Vargas, R. M. F., & Cassel, E. (2019). Extraction process of the Achyrocline satureioides (Lam) DC. essential oil by steam distillation: modeling, aromatic potential and fractionation. Journal of Essential Oil Research, 31(4), 286–296.
Prakash, B., Kedia, A., Mishra, P. K., & Dubey, N. K. (2015). Plant essential oils as food preservatives to control moulds, mycotoxin contamination and oxidative deterioration of agri-food commodities - Potentials and challenges. Food Control, 47, 381–391.
Prakash, B., Kujur, A., Yadav, A., Kumar, A., Singh, P. P., & Dubey, N. K. (2018). Nanoencapsulation: An efficient technology to boost the antimicrobial potential of plant essential oils in food system. Food Control, 89, 1–11.
Puri, M. (2017). Food bioactives: extraction and biotechnology applications. Springer.
Rai, M., Paralikar, P., Jogee, P., Agarkar, G., Ingle, A. P., Derita, M., & Zacchino, S. (2017). Synergistic antimicrobial potential of essential oils in combination with nanoparticles: Emerging trends and future perspectives. International Journal of Pharmaceutics, 519(1-2), 67-78.
Reyes-Jurado, F., Navarro-Cruz, A. R., Ochoa-Velasco, C. E., Palou, E., López-Malo, A., & Ávila-Sosa, R. (2020). Essential oils in vapor phase as alternative antimicrobials: A review. Critical Reviews in Food Science and Nutrition, 60(10), 1641–1650.
Sahne, F., Mohammadi, M., Najafpour, G. D., & Moghadamnia, A. A. (2016). Extraction of bioactive compound curcumin from turmeric (Curcuma longa L.) via different routes: A comparative study. Pakistan Journal of Biotechnology, 13(3), 173-180.
Sahraoui, N., & Boutekedjiret, C. (2015). Innovative process of essential oil extraction: steam distillation assisted by microwave. In Progress in Clean Energy, Volume 1 (pp. 831-841). Springer, Cham.
Sahraoui, N., Hazzit, M., & Boutekedjiret, C. (2017). Effects of microwave heating on the antioxidant and insecticidal activities of essential oil of Origanum glandulosum Desf. obtained by microwave steam distillation. Journal of Essential Oil Research, 29(5), 420–429.
Saifullah, M., Shishir, M. R. I., Ferdowsi, R., Tanver Rahman, M. R., & Van Vuong, Q. (2019). Micro and nanoencapsulation, retention and controlled release of flavor and aroma compounds: A critical review. Trends in Food Science and Technology, 86(September 2018), 230–251.
Saxena, J., Joshi, S., & Khan, M. A. (2015). Kinetic study of supercritical fluid extraction of essential oil from cumin (C. cyminum) seeds. Journal of Agricultural Engineering and Food Technology, 2(1), 32–38.
Swamy, M. K., Akhtar, M. S., & Sinniah, U. R. (2016). Antimicrobial properties of plant essential oils against human pathogens and their mode of action: an updated review. Evidence-Based Complementary and alternative medicine, 2016.
Tavakolpour, Y., Moosavi‐Nasab, M., Niakousari, M., Haghighi‐Manesh, S., Hashemi, S. M. B., & Mousavi Khaneghah, A. (2017). Comparison of four extraction methods for essential oil from Thymus daenensis Subsp. Lancifolius and chemical analysis of extracted essential oil. Journal of Food Processing and Preservation, 41(4), e13046.
Gavahian, M., Farahnaky, A., Javidnia, K., & Majzoobi, M. (2013). A novel technology for extraction of essential oil from Myrtus communis: ohmic-assisted hydrodistillation. Journal of Essential Oil Research, 25(4), 257-266.
Topala, C. M., & Tataru, L. D. (2016). ATR-FTIR Study of thyme and rosemary oils extracted by supercritical carbon dioxide. Revista de Chimie, 67(5), 842–846.
Twaij, B. M., & Hasan, M. N. (2022). Bioactive secondary metabolites from plant sources: types, synthesis, and their therapeutic uses. International Journal of Plant Biology, 13(1), 4-14.
Veiga, R. D. S. Da, Aparecida Da Silva-Buzanello, R., Corso, M. P., & Canan, C. (2019). Essential oils microencapsulated obtained by spray drying: a review. Journal of Essential Oil Research, 31(6), 457–473.
War, A. R., Buhroo, A. A., Hussain, B., Ahmad, T., Nair, R. M., & Sharma, H. C. (2020). Plant defense and insect adaptation with reference to secondary metabolites. In Co-Evolution of Secondary Metabolites (pp. 795-822). Springer, Cham.
Warsito, W., Noorhamdani, N., Sukardi, S., & Suratmo, S. (2018). Assessment of antioxidant activity of citronellal extract and fractions of essential oils of citrus hystrix DC. Tropical Journal of Pharmaceutical Research, 17(6), 1119–1125.
Yang, C., Chen, H., Chen, H., Zhong, B., Luo, X., & Chun, J. (2017). Antioxidant and anticancer activities of essential oil from gannan navel orange peel. Molecules, 22(8), 1–10.
Yousefi, M., Rahimi-Nasrabadi, M., Pourmortazavi, S. M., Wysokowski, M., Jesionowski, T., Ehrlich, H., & Mirsadeghi, S. (2019). Supercritical fluid extraction of essential oils. TrAC - Trends in Analytical Chemistry, 118, 182–193.
Zhang, Q. W., Lin, L. G., & Ye, W. C. (2018). Techniques for extraction and isolation of natural products: A comprehensive review. Chinese Medicine (United Kingdom), 13(1), 1–26.
Zhao, S., & Zhang, D. (2014). Supercritical CO2 extraction of Eucalyptus leaves oil and comparison with Soxhlet extraction and hydrodistillation methods. Separation & Purification Technology, 133, 443–451.
Zizovic, I., Senerovic, L., Moric, I., Adamovic, T., Jovanovic, M., Krusic, M. K., Misic, D., Stojanovic, D., & Milovanovic, S. (2018). Utilization of supercritical carbon dioxide in fabrication of cellulose acetate films with anti-biofilm effects against Pseudomonas aeruginosa and Staphylococcus aureus. Journal of Supercritical Fluids, 140, 11–20.